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USC scientists link variations in growth-factor gene to risk of prostate cancer

Bond In Investing Savings Two variations in the gene for insulin-like growth factor I (IGF-1) are linked to an increased risk of prostate cancer, according to research performed by scientists from the Keck School of Medicine of the University of Southern California, the Broad Institute of Harvard and MIT, and the University of Hawaii.

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Bond Investment Toledo Toledo "Our results suggest that inherited variation in IGF1 may play a role in prostate cancer risk," write the researchers in a paper published in the January 18, 2006, issue of the Journal of the National Cancer Institute.

Wilson was a research scientist at Stanford Medical Center, where she conducted research in the field of gene regulation of cancers related to steroid hormone receptors.

James Bond Trading Card USC scientists on this research team included: Iona Cheng, who was first author on the paper; Daniel Stram, Ph.D., professor of preventive medicine at the Keck School and the USC/Norris Comprehensive Cancer Center; Malcolm Pike, Ph.D., professor preventive medicine at the Keck School and USC/Norris; and Keck School of Medicine Dean Brian E. Henderson, M.D., who is also a distinguished professor in preventive medicine and neurology and the Kenneth T. Norris Jr. Chair in Cancer Prevention.

They also confirmed links between AMD susceptibility and variations in two other genes. Together, genetic variations in these three genes accounted for a large proportion of people's increased risk for AMD, the report found.

Bond In Investing Stock Cheng and her colleagues were able to tease out the relevant gene variations using data from the large Multiethnic Cohort study, for which Henderson is co-principal investigator. This population-based cohort study has collected data on more than 215,000 men and women from Los Angeles and Hawaii over the past decade.

Significant increases in testosterone levels in both men and women have been reported in some trials.^{36 37} Other reports have found this change in women but not in men.³⁸ An increase in testosterone might increase the risk of several cancers, and high amounts of DHEA have caused cancer in animals.^{39 40} Moreover, a possible link between higher DHEA levels and risks of prostate cancer in humans has been reported.⁴¹ At least one person with prostate cancer has been reported to have had a worsening of his cancer, despite feeling better, while taking very high amounts (up to 700 mg per day) of DHEA.⁴²

Municipal Bonds Investment From this cohort and information from cancer registries in California and Hawaii, the scientists were able to identify 2320 men who had developed prostate cancer and match them with 2290 men who did not have a prostate cancer diagnosis. This large population, the study's authors noted, provided "substantial [statistical] power to detect modest genetic effects."

A high level of lycopene in the blood serum correlates to a lower risk of prostate cancer, according to new research published in the latest edition of the American Journal of Epidemiology. Researchers from the US National Cancer Institute in Bethesda, Maryland, led by Dr Tara M. Vogt, focused on 437 men, some 209 of whom had prostate cancer. Vogt's team wanted to find conclusive evidence that the level of carotenoids such as lycopene found in the body were related to the incidence of prostate cancer, since earlier studies had given mixed results.

Bond Terms Trading The team knew that high circulating levels of IGF-1 had been linked by previous studies to an increase in prostate cancer risk, and so they focused on that gene and its single-nucleotide polymorphisms (SNPs): tiny point variations in the DNA code for a particular gene. What they found was that several SNPs across the gene were linked to an increased risk of prostate cancer, and two particular SNPs were identified that could account for the genetic associations they observed. Ten percent of the prostate cancer cases in this study could be explained by the variation in DNA sequence of these two polymorphisms.

Bond Debt High In Inside Because of the ethnic diversity in the cohort's population-included in the group are African Americans, Hawaiians, Japanese Americans, Latinos and whites-the researchers were also able to look at the risk associated with the two SNPs across the five different ethnic groups. As it turned out, the increase in risk was the same throughout all the sub-groups, "suggesting that the inherited variation in IFG1 behaves similarly among ancestral groups and shares an overall biologic effect," the researchers observed.

Bond Greenville Greenville "Our study critically evaluates the possibility of false positive results, and important issue faced by genetic association studies, and provides strong support for the involvement of the IGF pathway in the development of prostate cancer," Cheng noted. "By identifying the mechanisms in which inherited differences in IGF1 influence disease, we will further advance our understanding of prostate cancer biology and disease susceptibility."

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