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New screening test proves earlier, more accurate predictor for Down syndrome

Bond In Investing Savings Columbia-led study of more than 38,000 women enables faster, first trimester prenatal testing for leading cause of mental retardation and birth defects

Your caregiver will offer you screening tests that can give you information about your baby's risk of having Down syndrome and other chromosomal problems and birth defects. trimester screening options include a blood test that's done between 9 and 13 weeks. If it's available in your area, you'll also be offered a nuchal translucency screening, which is a type of ultrasound that's done at 11 to 13 weeks. Together, trimester combined screening.

Bond Investment Toledo Toledo A new study from Columbia University Medical Center researchers at NewYork-Presbyterian Hospital/Columbia of more than 38,000 pregnant women at 15 U.S. centers demonstrates the high accuracy of non-invasive screening for Down syndrome (also known as trisomy 21) in the first trimester of pregnancy, at 11 weeks. The findings are a significant advantage over the current standard screening, a blood test performed in the second trimester of pregnancy.

James Bond Trading Card "These results will undoubtedly change national practice - all pregnant women should have the option of early screening for Down syndrome in their first trimester," said Mary E. D'Alton, M.D., principal investigator of the study. She is Chair of the Department of Obstetrics and Gynecology at Columbia University College of Physicians and Surgeons, and Chief of Obstetrics and Gynecology at NewYork-Presbyterian Hospital/Columbia. "Down syndrome screenings based on either maternal age alone, or an ultrasound or sonogram alone, are no longer justified protocols."

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Bond In Investing Stock Published this week in the New England Journal of Medicine (Nov. 10, 2005 issue), the study is known as the FASTER trial (First and Second Trimester Evaluation of Risk). It was funded by a $13 million grant from the National Institutes of Health and the National Institute of Child Health and Human Development - one of the largest ever grants for an obstetrical study.

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Municipal Bonds Investment The new screening approach uses a blood test that analyzes the level of a protein and hormone in the mother's blood, combined with an ultrasound or sonogram picture of the thickness of skin on the back of the baby's neck (known as the nuchal translucency or NT). Results are available within five days, often before starting the second trimester of pregnancy. This combination approach determines the odds that the baby might have Down syndrome, allowing pregnant women the option of prenatal diagnosis for Down syndrome and other chromosomal abnormalities within the first trimester or pregnancy. The researchers found higher detection - 87 percent - in the first trimester compared to the best second trimester screening method - 81 percent detection. Results with this new combination screening approach in the first trimester are a significant advantage over the current standard screening test.

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Bond Terms Trading First-trimester screening was performed on 38,167 patients; 117 were found to have a fetus with Down syndrome. If a positive result was found via screening, the woman was given the option to have the finding confirmed with a diagnostic exam: chorionic villus sampling (CVS) or amniocentesis. Both tests carry risks of complication leading to miscarriage.

Bond Debt High In Inside Down syndrome is one of the leading causes of mental retardation and birth defects, found in one in 660 pregnancies. Persons with this condition have distinct physical features and commonly have certain birth defects and medical problems. Any woman can have a baby with Down syndrome, regardless of her age, race, health, economic status or family history. For this reason, most pregnant women undergo testing to determine their potential to have a baby with this syndrome.

Bond Greenville Greenville Dr. D'Alton and the research team believe that the new screening method should only be administered by qualified, trained physicians. Dr. D'Alton and other experts working with the Society of Maternal Fetal Medicine have recently formed the Maternal Fetal Medicine Foundation to facilitate physician training and quality review for the screening. So far 1,600 physicians and sonographers nationwide have undergone training, and more are scheduled. Information about the training and quality review program can be found at http://www.MFMF.org.

Trading Stock And Bonds Women seeking this early screening should seek healthcare professionals with appropriate ultrasound training and who participate in ongoing quality monitoring programs. Programs should provide sufficient information and resources for counseling regarding the different screening options and limitations of these tests. Additionally, the services should provide access to an appropriate diagnostic test when the screening test is positive.

Bond Investing Municipal "This study was a wonderfully collaborative effort between researchers, including four leading Obstetrics and Gynecology centers in New York City. This incredible achievement would not have been possible without the hard work of the 15 centers that comprised the FASTER Research Consortium and the 38,167 women who participated in this clinical trial," said Dr. D'Alton.

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